Case Study 10, Chapter 43, Disorders of the Male Reproductive System
No references needed,

Norris, T. (2019). Porth’s Pathophysiology: Concepts of Altered Health States. 10th Ed. Philadelphia
Case Study 10, Chapter 43, Disorders of the Male Reproductive System
No references needed,

Norris, T. (2019). Porth’s Pathophysiology: Concepts of Altered Health States. 10th Ed. Philadelphia

Darius is 63 years old and began to awake at night to urinate. When he went to the bathroom, he had to strain to initiate the flow, and the stream of urine was weak. Over time, the pattern became more apparent during the day; he often had a sense of urgency and felt he was going to the bathroom frequently. When he did, however, he did not always feel he had emptied his bladder, and he tended to dribble throughout the day. Much to his reluctance, his wife urged him to see a physician. At the doctor’s office, his case history was carefully taken, a digital rectal exam was performed, and lab work was ordered. His blood results were unremarkable, but his urinalysis showed an elevated white blood cell count and bacteria. His physician diagnosed Darius with benign prostatic hyperplasia and urinary tract infection.

1. How does BPH contribute to the signs and symptoms of bladder dysfunction, and how was Darius prone to developing a urinary tract infection?

2. What are the static and dynamic components of BPH? Why are α1-adrenergic receptor blockers sometimes used to treat prostatic hyperplasia?

3. How does the prostate feel during a digital rectal exam with benign prostatic hyperplasia, acute bacterial prostatitis, and prostate cancer?

4. Why does the patient with prostate cancer present with symptoms later in the disease?

Follow this Example.

Case Study, Chapter 4, Genetic Control of Cell Function and Inheritance Marsha and Clement are both carriers of sickle cell anemia, a disease that is autosomal recessive. Their first child, Amelia, does not have the disease. Marsha and Clement are planning another pregnancy, but they are concerned about their second child having the condition. Clement’s father died from complications of sickle cell disease shortly before Amelia was born

1. What is the likelihood of Marsha and Clement having a baby with sickle cell anemia? What is the chance the baby will be a carrier of the disease, just like the parents?

The gene is recessive, so the parents will have a 25% chance of giving birth to a child with the disease. There is a 50% chance that the baby will be a carrier

2. Marsha suggested to the nurse at the local family planning clinic that if the baby were a boy, he might have a higher risk of developing the disease, just like his grandfather. How would you respond?

The disease is autosomal in nature, meaning the disease arises from an abnormality on chromosomes 1 to 22. These chromosomes are alike in both males and females.

3. When Amelia, who does not have sickle cell anemia, grows up and marries someone who does have the disease, how likely will her children have the disease?

If Amelia has children to a father with sickle cell disease, the children will be carriers only.

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